Controlled drug delivery from porous hydroxyapatite grafts: An experimental and theoretical approach

Cylindrical hydroxyapatitic grafts at two different degree of porosity (60% and 40%) were tested as controlled drug delivery devices in order to evaluate the fundamental parameters which control release kinetics. The effect of device porosity, drug steric hindrance and drug loading on kinetics release has been appreciated using Ibuprofen-lysine and Hydrocortisone Na-succinate as non-steroidal and steroidal anti-inflammatory drug-models,...