Bone morphogenetic proteins in development and homeostasis of kidney
Abstract
Bone morphogenetic proteins play a key role in kidney development and postnatal function. The kidney has been identified as a major site of bone morphogenetic protein (BMP)-7 synthesis during embryonic and postnatal development, which mediates differentiation and maintenance of metanephric mesenchyme. Targeted disruption of BMP-7 gene expression in mice resulted in dysgenic kidneys with hydroureters, causing uremia within 24h after birth....
Paper Details
Title
Bone morphogenetic proteins in development and homeostasis of kidney
Published Date
Jun 1, 2005
Volume
16
Issue
3
Pages
299 - 308
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