Embedded Silica Nanoparticles in Poly(Caprolactone) Nanofibrous Scaffolds Enhanced Osteogenic Potential for Bone Tissue Engineering

Poly(caprolactone) (PCL) has been frequently considered for bone tissue engineering because of its excellent biocompatibility. A drawback, however, of PCL is its inadequate mechanical strength for bone tissue engineering and its inadequate bioactivity to promote bone tissue regeneration from mesenchymal stem cells. To correct this deficiency, this work investigates the addition of nanoparticles of silica (nSiO2) to the scaffold to take advantage...