Embedded Silica Nanoparticles in Poly(Caprolactone) Nanofibrous Scaffolds Enhanced Osteogenic Potential for Bone Tissue Engineering

Published on Aug 22, 2012in Tissue Engineering Part A3.496
· DOI :10.1089/TEN.TEA.2012.0167
Nitya Ganesh4
Estimated H-index: 4
(AIMS: Amrita Institute of Medical Sciences and Research Centre),
Rangasamy Jayakumar79
Estimated H-index: 79
+ 2 AuthorsShantikumar V. Nair75
Estimated H-index: 75
Poly(caprolactone) (PCL) has been frequently considered for bone tissue engineering because of its excellent biocompatibility. A drawback, however, of PCL is its inadequate mechanical strength for bone tissue engineering and its inadequate bioactivity to promote bone tissue regeneration from mesenchymal stem cells. To correct this deficiency, this work investigates the addition of nanoparticles of silica (nSiO2) to the scaffold to take advantage of the known bioactivity of silica as an osteogenic material and also to improve the mechanical properties through nanoscale reinforcement of the PCL fibers. The nanocomposite scaffolds and the pristine PCL scaffolds were evaluated physicochemically, mechanically, and biologically in the presence of human mesenchymal stem cells (hMSCs). The results indicated that, when the nanoparticles of size approximately 10 nm (concentrations of 0.5% and 1% w/v) were embedded within, or attached to, the PCL nanofibers, there was a substantial increase in scaffold strength, pro...
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