Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity

Purpose Plus disease has become the major criterion for laser treatment in infants with retinopathy of prematurity (ROP), but its assessment is subjective. Our purpose was to compare quadrant-level and eye-level assessment of plus disease and pre-plus disease among 3 experienced ROP examiners and to report their rate of agreement. Methods One hundred eighty-one high-quality RetCam images from premature infants were graded by 3 of the authors....