Downregulation of ΔNp63α in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation

The tumor suppressor p14ARF inhibits cell growth in response to oncogenic stress in a p53¬dependent and independent manner. However, new physiologic roles for ARF activation have been proposed. We have previously demonstrated that ARF interacts with p63, influencing its transcriptional activity. p63 is a member of the p53 family involved in skin and limb development, as well as in the homeostasis of mature epidermis. Here, we show that, in human...