Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
Abstract
P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1 gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer therapy. For several decades, P-gp inhibition has drawn many significant research efforts in an attempt to overcome this phenomenon. However, P-gp is also constitutively expressed in normal human epithelial tissues and, due to its broad substrate specificity, to its cellular polarized...
Paper Details
Title
Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
Published Date
May 1, 2015
Journal
Volume
149
Pages
1 - 123
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Notes
History