MDM2–p53 Pathway in Hepatocellular Carcinoma
Abstract
Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and negative regulator of p53, are commonly observed in cancers. The MDM2-p53 feedback loop plays an important role in tumor progression and thus, increased understanding of the pathway has the potential to improve clinical outcomes for cancer patients. Hepatocellular carcinoma (HCC) has emerged as one of the most commonly diagnosed forms of human cancer; yet,...
Paper Details
Title
MDM2–p53 Pathway in Hepatocellular Carcinoma
Published Date
Dec 15, 2014
Journal
Volume
74
Issue
24
Pages
7161 - 7167
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