Plasmacytoid Dendritic Cells Mediate Oral Tolerance

Volume: 29, Issue: 3, Pages: 464 - 475
Published: Sep 19, 2008
Abstract
Summary null Oral tolerance prevents oral sensitization to dietary antigens (Ags), including proteins and haptens, and development of delayed-type hypersensitivity (DTH) responses. We showed here that plasmacytoid dendritic cells (pDCs) prevented oral T cell priming and were responsible for systemic tolerance to CD4 + null and CD8 + null T cell-mediated DTH responses induced by Ag feeding. Systemic depletion of pDCs prevented induction of...
Paper Details
Title
Plasmacytoid Dendritic Cells Mediate Oral Tolerance
Published Date
Sep 19, 2008
Journal
Volume
29
Issue
3
Pages
464 - 475
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