Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
Abstract
The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the Crick strands of DNA, impede replication and transcription. Inappropriate repair of interstrand crosslinks causes genomic instability, leading to cancer; conversely, the toxicity of crosslinking agents makes them a powerful chemotherapeutic. Fanconi anaemia...
Paper Details
Title
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
Published Date
Jan 16, 2013
Journal
Volume
493
Issue
7432
Pages
356 - 363
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