Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8)
Abstract
Matrix metalloproteinases (MMPs) have been implicated in numerous tissue-remodeling processes. The finding that mice deficient in collagenase-2 (MMP-8) are more susceptible to develop skin cancer, prompted us to investigate the role of this protease in cutaneous wound healing. We have observed a significant delay in wound closure in MMP8−/− mice and an altered inflammatory response in their wounds, with a delay of neutrophil infiltration during...
Paper Details
Title
Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8)
Published Date
Mar 28, 2007
Journal
Volume
21
Issue
10
Pages
2580 - 2591
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