NMDA receptor dysfunction in autism spectrum disorders
Abstract
Abnormalities and imbalances in neuronal excitatory and inhibitory synapses have been implicated in diverse neuropsychiatric disorders including autism spectrum disorders (ASDs). Increasing evidence indicates that dysfunction of NMDA receptors (NMDARs) at excitatory synapses is associated with ASDs. In support of this, human ASD-associated genetic variations are found in genes encoding NMDAR subunits. Pharmacological enhancement or suppression...
Paper Details
Title
NMDA receptor dysfunction in autism spectrum disorders
Published Date
Feb 1, 2015
Volume
20
Pages
8 - 13
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