Acquired palmoplantar keratoderma.

Published on Jan 1, 2007in American Journal of Clinical Dermatology5.056
· DOI :10.2165/00128071-200708010-00001
Shaily Patel2
Estimated H-index: 2
(University of Pittsburgh),
Matthew J. Zirwas22
Estimated H-index: 22
(OSU: Ohio State University),
Joseph C. English21
Estimated H-index: 21
(University of Pittsburgh)
Palmoplantar keratodermas (PPKs) are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. Traditionally they have been classified as either hereditary or acquired and are distinguished from each other on the basis of mode of inheritance, presence of transgrediens (defined as contiguous extension of hyperkeratosis beyond the palmar and/or plantar skin), co-morbidities with other symptoms, and extent of epidermal involvement, namely diffuse, focal, and punctate. As the terms hyperkeratosis and keratoderma have been used interchangeably throughout the literature, we define acquired keratoderma as a non-hereditary, non-frictional hyperkeratosis of the palms and/or soles that involves ≥50% of the surface of involved acral areas and that may or may not be associated with clinical and histologic inflammation.
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