Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT ☆

Published on Sep 1, 2010in Bone4.398
· DOI :10.1016/J.BONE.2010.05.034
Andrew J. Burghardt54
Estimated H-index: 54
(UCSF: University of California, San Francisco),
Helen R. Buie12
Estimated H-index: 12
(U of C: University of Calgary)
+ 2 AuthorsSteven K. Boyd51
Estimated H-index: 51
(U of C: University of Calgary)
Sources
Abstract
Abstract Quantitative cortical microarchitectural end points are important for understanding structure–function relations in the context of fracture risk and therapeutic efficacy. This technique study details new image-processing methods to automatically segment and directly quantify cortical density, geometry, and microarchitecture from HR-pQCT images of the distal radius and tibia. An automated segmentation technique was developed to identify the periosteal and endosteal margins of the distal radius and tibia and detect intracortical pore space morphologically consistent with Haversian canals. The reproducibility of direct quantitative cortical bone indices based on this method was assessed in a pooled data set of 56 subjects with two repeat acquisitions for each site. The in vivo precision error was characterized using root mean square coefficient of variation (RMSCV%) from which the least significant change (LSC) was calculated. Bland–Altman plots were used to characterize bias in the precision estimates. The reproducibility of cortical density and cross-sectional area measures was high (RMSCV p This study indicates that HR-pQCT measures of cortical bone density and architecture can be measured in vivo with high reproducibility and limited bias across a biologically relevant range of values. The results of this study provide informative data for the design of future clinical studies of bone quality.
📖 Papers frequently viewed together
References31
Newest
#1X. Sherry Liu (Columbia University)H-Index: 37
#2X. Henry Zhang (Columbia University)H-Index: 8
Last. X. Edward Guo (Columbia University)H-Index: 66
view all 10 authors...
Micro magnetic resonance imaging (µMRI) is an in vivo imaging method that permits 3D quantification of cortical and trabecular bone microstructure. µMR images can also be used for building microstructural finite element (µFE) models to assess bone stiffness, which highly correlates with bone's resistance to fractures. In order for µMRI-based microstructural and µFE analyses to become standard clinical tools for assessing bone quality, validation with a current gold standard, namely, high-resolut...
Source
#1L. J. Melton (Mayo Clinic)H-Index: 37
#2David Christen (ETH Zurich)H-Index: 9
Last. Sundeep Khosla (Mayo Clinic)H-Index: 132
view all 9 authors...
Summary A diverse array of bone density, structure, and strength parameters were significantly associated with distal forearm fractures in postmenopausal women, but most of them were also correlated with femoral neck areal bone mineral density (aBMD), which provides an adequate measure of bone fragility at the wrist for routine clinical purposes.
Source
#1Babul Borah (P&G: Procter & Gamble)H-Index: 11
#2T.E. Dufresne (P&G: Procter & Gamble)H-Index: 5
Last. Ego Seeman (University of Melbourne)H-Index: 108
view all 10 authors...
Nonvertebral fractures account for 80% of all fractures and their accompanying morbidity and mortality. Despite this, the effect of drug therapy on cortical morphology has received limited attention, partly because cortical bone is believed to remodel less and decrease less with age than trabecular bone. However, the haversian canals traversing the cortex provide a surface for remodeling that produces bone loss, porosity, and cortical fragility. We developed a new method of 3D micro-computed tom...
Source
#1Andrew J. Burghardt (UCSF: University of California, San Francisco)H-Index: 54
#2Galateia J. Kazakia (UCSF: University of California, San Francisco)H-Index: 27
Last. Sharmila Majumdar (University of California, Berkeley)H-Index: 105
view all 5 authors...
Cortical bone contributes the majority of overall bone mass and bears the bulk of axial loads in the peripheral skeleton. Bone metabolic disorders often are manifested by cortical microstructural changes via osteonal remodeling and endocortical trabecularization. The goal of this study was to characterize intracortical porosity in a cross-sectional patient cohort using novel quantitative computational methods applied to high-resolution peripheral quantitative computed tomography (HR-pQCT) images...
Source
#1Kyle K. Nishiyama (U of C: University of Calgary)H-Index: 27
#2Heather M. Macdonald (U of C: University of Calgary)H-Index: 31
Last. Steven K. Boyd (U of C: University of Calgary)H-Index: 51
view all 5 authors...
Increases in cortical porosity (Ct.Po) and decreases in cortical thickness (Ct.Th) are associated with increased bone fragility. The purpose of this study was to validate an autosegmentation method for high-resolution peripheral quantitative computed tomography (HR-pQCT) scans to measure Ct.Po and Ct.Th and use it to compare Ct.Po and Ct.Th between pre- and postmenopausal women with normal, osteopenic, and osteoporotic areal bone mineral density (aBMD). The Ct.Po and Ct.Th measurements were vali...
Source
#1X. Sherry Liu (Columbia University)H-Index: 37
#2X. Henry Zhang (Columbia University)H-Index: 8
Last. X. Edward Guo (Columbia University)H-Index: 66
view all 8 authors...
High-resolution peripheral quantitative computed tomography (HR-pQCT) is a newly developed in vivo clinical imaging modality. It can assess the 3D microstructure of cortical and trabecular bone at the distal radius and tibia and is suitable as an input for microstructural finite element (µFE) analysis to evaluate bone's mechanical competence. In order for microstructural and image-based µFE analyses to become standard clinical tools, validation with a current gold standard, namely, high-resoluti...
Source
#1Ralph Müller (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 113
#2T. Hildebrand (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 10
Last. P Rüegsegger (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 26
view all 4 authors...
Trabecular bone architecture is one of the main factors influencing the mechanical behavior of cancellous bone. To assess the three-dimensional trabecular microstructure of intact bones, we introduced the concept of noninvasive bone biopsy, a method to assess and analyze cancellous bone based upon three-dimensional peripheral quantitative computed tomography in vivo (3D-pQCT). The aim of this work was to demonstrate the potential of noninvasive bone biopsies as a basis for structural and mechani...
Source
#1Kiranjit Sekhon (UCSF: University of California, San Francisco)H-Index: 1
#2Galateia J. Kazakia (UCSF: University of California, San Francisco)H-Index: 27
Last. Sharmila Majumdar (UCSF: University of California, San Francisco)H-Index: 105
view all 5 authors...
Abstract Accurate bone mineral density (BMD) quantification is critical in clinical assessment of fracture risk and in the research of age-, disease-, and treatment-related musculoskeletal changes. The development of high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging has made possible in vivo assessment of compartmental volumetric BMD (vBMD) and bone micro-architecture in the distal radius and tibia. HR-pQCT imaging relies on a polychromatic X-ray source and therefore ...
Source
#1Babul Borah (P&G: Procter & Gamble)H-Index: 11
#2T.E. Dufresne (P&G: Procter & Gamble)H-Index: 5
Last. Ego Seeman (University of Melbourne)H-Index: 108
view all 9 authors...
Source
#1Elisabeth Sornay-Rendu (University of Lyon)H-Index: 40
#2Jose-Luis Cabrera-Bravo (University of Lyon)H-Index: 1
Last. Pierre D. Delmas (University of Lyon)H-Index: 159
view all 5 authors...
Patients with vertebral fractures (VFx) have trabecular architectural disruption on iliac biopsies. Because cortical bone is an important determinant of bone strength, we assessed cortical and trabecular microarchitecture at peripheral sites in patients with VFx of varying number (N) and severity (S). Bone architecture and volumetric density (vBMD) were assessed at the distal radius and tibia with HR-pQCT (XTreme CT; Scanco Medical, Bassersdorf, Switzerland) in 100 women with VFx (age, 74 ± 9 yr...
Source
Cited By343
Newest
#1M.S.A.M. Bevers (TU/e: Eindhoven University of Technology)H-Index: 2
#3B. van Rietbergen (TU/e: Eindhoven University of Technology)H-Index: 20
Abstract null null Improving the clinical outcome of scaphoid fractures may benefit from adequate monitoring of their healing in order to for example identify complications such as scaphoid nonunion at an early stage and to adjust the treatment strategy accordingly. However, quantitative assessment of the healing process is limited with current imaging modalities. In this study, high-resolution peripheral quantitative computed tomography (HR-pQCT) was used for the first time to assess the change...
Source
#1Fjola Johannesdottir (Harvard University)H-Index: 11
#2Melissa S. Putman (Harvard University)H-Index: 12
Last. Mary L. Bouxsein (Harvard University)H-Index: 107
view all 6 authors...
Higher fracture risk in White versus Black women is partly explained by lower BMD and worse bone microarchitecture in White women. However, whether rates of decline in bone density, microarchitecture and strength differ between postmenopausal Black and White women is unknown. Further, factors that influence rates of age-related bone microarchitecture deterioration remain ill-defined. Thus, over 6.7 years, we measured longitudinal changes in peripheral volumetric bone mineral density (vBMD), micr...
Source
#1Lauren A Burt (U of C: University of Calgary)H-Index: 15
Last. Steven K. Boyd (U of C: University of Calgary)H-Index: 51
view all 4 authors...
Abstract null null Objectives null In elite figure skaters, to determine if there was a difference in volumetric bone mineral density and bone strength between 1) figure skaters and population-based normative data, 2) single or pair skaters and ice dancers, and 3) the landing and takeoff legs. null null null Design null Cross-sectional. null null null Methods null Figure skaters had their non-dominant distal radius and bilateral tibia scanned using high-resolution peripheral quantitative compute...
Source
#1Meiling Huang (Southern Medical University)
#2Vivian W. Y. Hung (CUHK: The Chinese University of Hong Kong)H-Index: 18
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 88
view all 7 authors...
Volumetric bone density (vBMD) and trabecular microarchitecture measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) can discriminate the patients with high risk of asymptomatic vertebral fracture (VF) in postmenopausal Chinese women. These findings suggested that HR-pQCT could provide additional information on bone quality of the patients with asymptomatic VF. INTRODUCTION Although there were several studies using HR-pQCT to investigate asymptomatic VF, it remains u...
Source
#1Gabriele Armbrecht (Humboldt University of Berlin)H-Index: 27
#2Huong Nguyen Minh (Humboldt University of Berlin)
Last. Kay Raum (Humboldt University of Berlin)H-Index: 4
view all 4 authors...
Source
Context Men with Congenital Hypogonadotropic Hypogonadism (CHH) and Kallmann syndrome (KS) have both low circulating testosterone and estradiol levels. Whether bone structure is affected remains unknown. Objective To characterize bone geometry, volumetric density and microarchitecture in CHH/KS. Design Cross-sectional study. Setting One tertiary academic French center. Patients and controls 51 genotyped CHH/KS patients and 40 healthy volunteers were included. Ninety-eight percent of CHH/KS men h...
Source
#1E. C. Herbst (UZH: University of Zurich)H-Index: 2
#2Alessandro Felder (UCL: University College London)H-Index: 5
Last. Andrew A. Pitsillides (RVC: Royal Veterinary College)H-Index: 47
view all 6 authors...
Many physiological, biomechanical, evolutionary and clinical studies that explore skeletal structure and function require successful separation of trabecular from cortical compartments of a bone th...
Source
#1Scott C Brunet (U of C: University of Calgary)H-Index: 3
#2Stephanie Finzel (University of Freiburg)H-Index: 27
Last. Sarah L. Manske (U of C: University of Calgary)H-Index: 18
view all 6 authors...
Resume null null Objectifs null L’apparition d’erosions dans les arthropathies inflammatoires revet une importance majeure car elles ont une incidence sur le pronostic et les decisions therapeutiques. Notre etude visait a determiner la sensibilite de la tomodensitometrie quantitative peripherique haute resolution (HR-pQCT) pour detecter des changements de la surface osseuse au cours du temps et identifier l’apparition d’erosions chez les patients presentant une arthrite inflammatoire precoce (AI...
Source
#1Anna L. Eriksson (University of Gothenburg)H-Index: 16
#2Nele Friedrich (Greifswald University Hospital)H-Index: 30
Last. Claes Ohlsson (University of Gothenburg)H-Index: 119
view all 9 authors...
Context null In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD). null Objective null To investigate associations for serum and urinary glycine levels with BMD, bone microstructure and fracture risk in men. null Methods null In the population based MrOS Sweden study (men, 69-81 years) serum glycine and BMD were measured at baseline (n=965) and 5-year follow up (n=546). Cortical and trabecular bone parameters of the distal tibia were ...
Source
#1Kurt N. Hildebrand (U of C: University of Calgary)H-Index: 1
#2Karamjot Sidhu (U of C: University of Calgary)H-Index: 1
Last. Steven K. Boyd (U of C: University of Calgary)H-Index: 51
view all 6 authors...
BACKGROUND Peripheral quantitative computed tomography (pQCT) is the current densitometric gold-standard for assessing skeletal muscle at the 66% proximal tibia site. High resolution peripheral quantitative computed tomography (HR-pQCT) is a leading technology for quantifying bone microarchitecture at the distal extremities, and with the second-generation HR-pQCT it is possible to measure proximal limb sites. Therefore, the objectives of this study were to: (1) assess the feasibility of using HR...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.