HLA‐E*0101 and HLA‐G*010101 reduce the risk of Behcet’s disease

The nonclassical human leukocyte antigen (HLA)‐E and ‐G molecules have previously been shown to inhibit natural killer‐ and cytotoxic T‐lymphocyte‐mediated cell lysis and have also been shown to prevent the proliferation of CD4 T cells and secrete cytokines that appear to be important in the modulation of the Behcet’s disease (BD) immune systems. Polymorphisms in the HLA‐E and HLA‐G genes have been associated with differential expression and...