Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry
Abstract
Following the increase in development of protein biopharmaceuticals, there is a growing demand for the sensitive and reliable quantification of these proteins in complex biological matrices such as plasma and serum to support (pre)-clinical research. In this field, ligand binding assays (LBAs) are currently the standard analytical technique, but in recent years, there is a trend towards the use of liquid chromatography hyphenated with (tandem)...
Paper Details
Title
Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry
Published Date
Apr 1, 2012
Journal
Volume
893-894
Pages
1 - 14
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