Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis

It has been recently demonstrated that interleukin 1β (IL-1β) plays a central role in monosodium urate crystal–induced inflammation and that the NALP3 inflammasome plays a major role in IL-1β production. These discoveries have offered new insights into the pathogenesis of acute gouty arthritis. In this review, we discuss the molecular mechanisms by which monosodium urate crystals induce acute inflammation and examine the mechanisms of action...