TOLL-LIKE RECEPTOR 4 CONTRIBUTES TO MICROVASCULAR INFLAMMATION AND BARRIER DYSFUNCTION IN THERMAL INJURY

Systemic and microvascular inflammation plays a key role in the development of multiple organ failure after infection, sepsis, and traumatic injury. Toll-like receptors (TLRs) regulate host responses to pathogens and sterile, injury-associated inflammatory responses. We investigated whether TLR-4 contributes to microvascular dysfunction during thermal injury in vivo in anesthetized wild-type or TLR-4−/− mice receiving either a 25% total body...