Chromosomal breakage syndromes and the BRCA1 genome surveillance complex.
Abstract
Chromosomal instability can occur when the DNA damage response and repair process fails, resulting in syndromes characterized by growth abnormalities, hematopoietic defects, mutagen sensitivity, and cancer predisposition. Mutations in ATM, NBS1, MRE11, BLM, WRN, and FANCD2 are responsible for ataxia telangiectasia (AT), Nijmegen breakage syndrome, AT-like disorder, Bloom and Werner syndrome, and Fanconi anemia group D2, respectively. This...
Paper Details
Title
Chromosomal breakage syndromes and the BRCA1 genome surveillance complex.
Published Date
Dec 1, 2001
Journal
Volume
7
Issue
12
Pages
560 - 565
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