Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer
Volume: 382, Issue: 1, Pages: 616 - 621
Published: Jan 1, 2014
Abstract
The transcription factors STAT3 and STAT5 play important roles in the regulation of mammary gland function during pregnancy, lactation, and involution. Given that STAT3 and STAT5 regulate genes involved in proliferation and survival, it is not surprising that inappropriate activation of STAT3 and STAT5 occurs commonly in breast cancer. Although these proteins are structurally similar, they have divergent and opposing effects on gene expression...
Paper Details
Title
Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer
Published Date
Jan 1, 2014
Volume
382
Issue
1
Pages
616 - 621
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