A model for quantitative measurement of sulfur mustard skin lesions in the rabbit ear

The search for treatment and protection against the vesicant and inflammatory skin lesions induced by sulfur mustard suffers from the lack of a good in vivo reproducible model. We applied sulfur mustard (25–500 μg/cm2) to the outer surface of the ears of 10 rabbits and measured the edema formation 12, 24 and 48 h post-application with a caliper especially designed for soft matter. There was a dose-dependent linear increase in edema magnitude in...