Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft-versus-host disease?

Summary Pre‐transplant conditioning regimens play a major role in triggering graft‐versus‐host disease ( GVHD ). This study investigated the effect of irradiation on donor T cell trafficking to lymphoid and non‐lymphoid tissues by comparing the migration of carboxy‐fluorescein diacetate succinimidyl ester‐labelled, naïve donor T lymphocytes in vivo in irradiated and non‐irradiated syngeneic mice recipients. Recruitment of adoptively transferred...