The Hippo pathway and human cancer

Published on Apr 1, 2013in Nature Reviews Cancer53.03
· DOI :10.1038/NRC3458
Kieran F. Harvey36
Estimated H-index: 36
(University of Melbourne),
Xiaomeng Zhang13
Estimated H-index: 13
(University of Melbourne),
David Thomas144
Estimated H-index: 144
(University of Melbourne)
A wealth of recent studies has characterized roles for the Hippo pathway in diverse cancer-relevant processes. This Review discusses our latest understanding of Hippo pathway signalling in cancer, including mechanisms of pathway disruption in cancer, and the opportunities and challenges for therapeutic intervention.
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