Involvement of Müller glial cells in epiretinal membrane formation

Background Proliferative retinopathies are considered to represent maladapted retinal wound repair processes driven by growth factor- and cytokine-induced overstimulation of proliferation, migration, extracellular matrix production and contraction of retinal cells. The formation of neovascular membranes represents an attempt to reoxygenize non-perfused retinal areas. Muller glial cells play a crucial role in the pathogenesis of proliferative...