Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Abstract
Six members of the mammalian transient receptor potential (TRP) ion channels respond to varied temperature thresholds. The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively. The burning and cooling perception of capsaicin and menthol demonstrate that these ion channels mediate thermosensation. We show that, in addition to noxious cold, pungent natural compounds present in...
Paper Details
Title
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Published Date
Mar 1, 2004
Journal
Volume
41
Issue
6
Pages
849 - 857
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