Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

Volume: 16, Issue: 19, Pages: 8781 - 8794
Published: Oct 1, 2008
Abstract
Zn-metalloproteinases are an important class of hydrolytic enzymes that are characterized by the presence of a catalytic zinc(II) atom in their active center which is fundamental for proteolytic activity. Metzincins, a superfamily of Zn-metalloproteinases with many structural and functional commonalities among its members, are responsible for the fine tuning of key physiological functions in mammals and the deregulation of their activity is...
Paper Details
Title
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Published Date
Oct 1, 2008
Volume
16
Issue
19
Pages
8781 - 8794
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