Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
Abstract
Recent data have suggested a relationship between acute arthritic pain and acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The purpose of this study was to clarify the role of ASIC3 in a rat model of osteoarthritis (OA) which is considered a degenerative rather than an inflammatory disease. We induced OA via intra-articular mono-iodoacetate (MIA) injection, and evaluated pain-related behaviors including weight...
Paper Details
Title
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
Published Date
Aug 21, 2012
Volume
19
Issue
1
Pages
77 - 77
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