Phototransduction by retinal ganglion cells that set the circadian clock.

Science56.90
Volume: 295, Issue: 5557, Pages: 1070 - 1073
Published: Feb 8, 2002
Abstract
Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when...
Paper Details
Title
Phototransduction by retinal ganglion cells that set the circadian clock.
Published Date
Feb 8, 2002
Journal
Volume
295
Issue
5557
Pages
1070 - 1073
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