Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?
Abstract
Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of...
Paper Details
Title
Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?
Published Date
May 1, 2008
Journal
Volume
73
Issue
9
Pages
989 - 991
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