Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies

Volume: 38, Issue: 9, Pages: 2499 - 2511
Published: Sep 1, 2008
Abstract
Immunostimulatory mAb as vaccine adjuvants for the treatment of cancer hold considerable potential for boosting weak responses when used against immunogenic tumours, or in combination with various other vaccines. We now show that when administered with OVA, the combination of anti-4-1BB mAb with anti-CD40, anti-OX40 or anti-CD25 resulted in a fourfold enhancement in the antigen-specific T-cell response compared with anti-4-1BB mAb alone, with a...
Paper Details
Title
Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies
Published Date
Sep 1, 2008
Volume
38
Issue
9
Pages
2499 - 2511
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