Iodoacetic acid, but not sodium iodate, creates an inducible swine model of photoreceptor damage
Abstract
Our purpose was to find a method to create a large animal model of inducible photoreceptor damage. To this end, we tested in domestic swine the efficacy of two chemical toxins, known to create photoreceptor damage in other species: Iodoacetic Acid (IAA) and Sodium Iodate (NaIO(3)). Intravenous (IV) administration of NaIO(3) up to 90 mg/kg had no effect on retinal function and 110 mg/kg was lethal. IV administration of IAA (5-20 mg/kg) produced...
Paper Details
Title
Iodoacetic acid, but not sodium iodate, creates an inducible swine model of photoreceptor damage
Published Date
Apr 1, 2012
Journal
Volume
97
Issue
1
Pages
137 - 147
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