PULMONARY EFFECTS OF INHALED ZINC OXIDE IN HUMAN SUBJECTS, GUINEA PIGS, RATS, AND RABBITS

Occupational exposure to freshly formed zinc oxide (ZnO) particles (<1.0 µm aerodynamic diameter) produces a well-characterized response known as metal fume fever. An 8-hr threshold limit value (TLV) of 5 mg/m3 has been established to prevent adverse health effects because of exposure to ZnO fumes. Because animal toxicity studies have demonstrated pulmonary effects near the current TLV, the present study examined the time course and...