Hybrids of Nonviral Vectors for Gene Delivery

Gene transfer has been a critical step for gene therapy. Viral vectors and nonviral vectors are commonly used for gene transfer. It has been shown that nonviral vectors have the advantage over viral ones, as they are nonimmunogenic, easy to produce, and not oncogenic. However, they have the major limitation of inefficient transfection; the hybridized usage of nonviral vectors may provide a partial solution. This article reviews the hybrids...