ADMA and SDMA predict outcomes in patients with chronic atrial fibrillation: an ARISTOTLE substudy

Purpose: Anticoagulant-treated elderly patients with paroxysmal or sustained atrial fibrillation (AF) are at increased risk not only of thrombo-embolism, but also of major bleeds and of cardiac death. The methylated arginine derivatives asymmetric and symmetric dimethylarginine (ADMA/SDMA) modulate vascular function, partially by inhibiting nitric oxide generation, and thus may potentially modulate these risks. We therefore evaluated the...