LPS or ethanol triggers clathrin‐ and rafts/caveolae‐dependent endocytosis of TLR 4 in cortical astrocytes
Abstract
Toll‐like receptor 4 (TLR4) activation and signalling in glial cells play critical roles in neurological disorders and in alcohol‐induced brain damage. TLR4 endocytosis upon lipopolysaccharide (LPS) stimulation regulates which signalling pathway is activated, the MyD88‐dependent or the TIR‐domain‐containing adapter‐inducing interferon‐β ( TRIF )‐dependent pathway. However, it remains elusive whether ethanol‐induced TLR 4 signalling is associated...
Paper Details
Title
Published Date
Jan 5, 2014
Journal
Volume
129
Issue
3
Pages
448 - 462
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