Minireview: Hair cortisol: a novel biomarker of hypothalamic-pituitary-adrenocortical activity.

Published on Jul 9, 2012in Endocrinology4.736
路 DOI :10.1210/EN.2012-1226
Jerrold S. Meyer47
Estimated H-index: 47
(UMass: University of Massachusetts Amherst),
Melinda A. Novak45
Estimated H-index: 45
(UMass: University of Massachusetts Amherst)
Sources
Abstract
Activity of the hypothalamic-pituitary-adrenocortical (HPA) axis is commonly assessed by measuring glucocorticoids such as cortisol (CORT). For many years, CORT was obtained primarily from blood plasma or urine, whereas later approaches added saliva and feces for noninvasive monitoring of HPA functioning. Despite the value of all these sample matrices for answering many research questions, they remain limited in the temporal range of assessment. Plasma and saliva are point samples that vary as a function of circadian rhythmicity and are susceptible to confounding by environmental disturbances. Even urine and feces generally assess HPA activity over a period of only 24 h or less. We and others have recently developed and validated methods for measuring the concentration of CORT in the body hair of animals (e.g. rhesus monkeys) and scalp hair of humans. CORT is constantly deposited in the growing hair shaft, as a consequence of which such deposition can serve as a biomarker of integrated HPA activity over weeks and months instead of minutes or hours. Since the advent of this methodological advance, hair CORT has already been used as an index of chronic HPA activity and stress in human clinical and nonclinical populations, in a variety of laboratory-housed and wild-living animal species, and in archival specimens that are many decades or even centuries old. Moreover, because human hair is known to grow at an average rate of about 1 cm/month, several studies suggest that CORT levels in hair segments that differ in proximity to the scalp can, under certain conditions, be used as a retrospective calendar of HPA activity during specific time periods preceding sample collection.
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#8Qiang Wang (Sichuan University)H-Index: 33
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#3R. Dietz (AU: Aarhus University)H-Index: 13
abstract The multivariate relationship between hair cortisol, whole blood thyroid hormones, and the complexmixtures of organohalogen contaminant (OHC) levels measured in subcutaneous adipose of 23 EastGreenland polar bears (eight males and 15 females, all sampled between the years 1999 and 2001) wasanalyzed using projection to latent structure (PLS) regression modeling. In the resulting PLS model,most important variables with a negative in铿倁ence on cortisol levels were particularly BDE-99, but a...
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a b s t r a c t Hair cortisol concentrations (HCC) are assumed to reflect integrated cortisol secretion over extended periods of time and may provide a sensitive marker for stress-associated endocrine changes. Here, we report data from two independent studies of 155 (study I) and 58 participants (study II) in which HCC associations with different stress-related measures and body mass index (BMI) were investigated. Con- sistent evidence for positive associations between HCC and BMI was seen acros...
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Summary The analysis of cortisol in human hair constitutes a promising method for the retrospective assessment of cumulative cortisol secretion over extended periods of time. An implicit assumption underlying the use of this method is that in the absence of major life changes hair cortisol concentrations show a high level of intraindividual stability, i.e. single hair cortisol assessments exhibit considerable trait-specificity and are only to a smaller extent influenced by state-dependent factor...
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Summary Increased hair cortisol concentrations have been associated with stress exposure in both human and nonhuman primates, and hair cortisol is now gaining attention as a biomarker for stress-related health problems. The present study examined the behavioral and physiological reactions of rhesus monkey ( Macaca mulatta ) infants reared in three different rearing environments to the major stressor of relocation. Infant monkeys ( n =聽61) were studied from birth through 2 years of age. For the f...
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