Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2.

Volume: 33, Issue: 26, Pages: 6113 - 6122
Published: Sep 1, 2012
Abstract
Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor, yet its clinical use is limited by a short biological half-life, rapid local clearance and propensity for side effects. Heparin (HP), a highly sulfated glycosaminoglycan (GAG) that avidly binds BMP-2, has inherent biological properties that may circumvent these limitations. Here, we compared hyaluronan-based hydrogels formulated to include heparin (Heprasil™) with similar...
Paper Details
Title
Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2.
Published Date
Sep 1, 2012
Volume
33
Issue
26
Pages
6113 - 6122
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