What can we learn from fitness landscapes?
Abstract
A combinatorially complete data set consists of studies of all possible combinations of a set of mutant sites in a gene or mutant alleles in a genome. Among the most robust conclusions from these studies is that epistasis between beneficial mutations often shows a pattern of diminishing returns, in which favorable mutations are less fit when combined than would be expected. Another robust inference is that the number of adaptive evolutionary...
Paper Details
Title
What can we learn from fitness landscapes?
Published Date
Oct 1, 2014
Volume
21
Pages
51 - 57
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Notes
History