Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
Abstract
Rhinovirus (RV) infections trigger asthma exacerbations. Genome-wide expression analysis of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was performed to determine whether asthma is associated with a unique pattern of RV-induced gene expression. Virus replication rates were similar in cells from normal and asthmatic donors. Overall, RV downregulated 975 and upregulated 69 genes. Comparisons of transcriptional...
Paper Details
Title
Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
Published Date
Jan 1, 2010
Journal
Volume
3
Issue
1
Pages
69 - 80
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