Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases
Abstract
Pin1 isomerizes the bonds of molecules important for numerous oncogenic and cell-signaling pathways, including Bcl-2, p53, c-Jun, beta-catenin, NF-kappaB, cyclin D1, c-Myc and Raf-1. This can cause a change in conformation leading to alterations in catalytic activity, protein-protein interactions, subcellular localization and protein stability. These alterations have been shown to be associated with cell transformation and cancer progression....
Paper Details
Title
Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases
Published Date
Apr 1, 2007
Journal
Volume
56
Issue
1
Pages
51 - 58
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