Black mamba venom peptides target acid-sensing ion channels to abolish pain
Abstract
Polypeptide toxins have played a central part in understanding physiological and physiopathological functions of ion channels. In the field of pain, they led to important advances in basic research and even to clinical applications. Acid-sensing ion channels (ASICs) are generally considered principal players in the pain pathway, including in humans. A snake toxin activating peripheral ASICs in nociceptive neurons has been recently shown to evoke...
Paper Details
Title
Black mamba venom peptides target acid-sensing ion channels to abolish pain
Published Date
Oct 3, 2012
Journal
Volume
490
Issue
7421
Pages
552 - 555
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