Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model

Epithelial cell migration during wound healing is regulated in part by enzymatic processing of laminin‐332 (formerly LN‐5), a heterodimer formed from α, β, and γ polypeptide chains. Under static conditions, laminin‐332 is secreted into the extracellular matrix as a proform and has two chains processed to smaller forms, allowing it to anchor epithelial cells to the basement membrane of the dermis. During incisional wounding, laminin γ2 chains in...