The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors.
Abstract
Background
The ERK MAP kinase pathway plays a pivotal role in growth factor-induced gene expression. However, genes whose expression is induced by the ERK pathway are not fully defined.
Results
We have identified SGK (serum- and glucocorticoid-inducible kinase) as an ERK-inducible gene by the subtractive screening of Raf-inducible genes. SGK is known to be similar in primary structure to AKT/PKB, PKC and PKA. Treatment of quiescent...
Paper Details
Title
The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors.
Published Date
Mar 1, 2001
Journal
Volume
6
Issue
3
Pages
261 - 268
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Notes
History