Akt acutely activates the cholesterogenic transcription factor SREBP-2.
Abstract
Akt is an essential protein kinase for cell growth, proliferation, and survival. Perturbed Akt regulation is associated with a number of human diseases, such as cancer and diabetes. Recently, evidence has emerged that Akt is involved in the regulation of the sterol-regulatory element binding proteins, which are master transcriptional regulators of lipid metabolism. This offers a means by which synthesis of new membrane can be coordinated with...
Paper Details
Title
Akt acutely activates the cholesterogenic transcription factor SREBP-2.
Published Date
Feb 1, 2012
Volume
1823
Issue
2
Pages
458 - 464
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