A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice
Abstract
Dengue viruses co-circulate as four serologically distinct viruses (DENV1–4) that commonly infect individuals sequentially. Current DENV candidate vaccines incorporate the entire virion envelope E protein (E) ectodomain thereby stimulating both DENV serotype-specific and cross-reactive antibodies. Because the latter may enhance naturally acquired infection, such vaccine formulations must be tetravalent. We evaluated the neutralizing and...
Paper Details
Title
A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice
Published Date
Nov 1, 2010
Journal
Volume
28
Issue
51
Pages
8085 - 8094
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