Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology

This review aims to summarize the evidence that Notch signaling is associated with prostate development, tumorigenesis and prostate tumor progression. Studies in PubMed database were searched using the keywords of Notch signaling, prostate development and prostate cancer. Relevant literatures were identified and summarized. The Notch pathway plays an important role in determining cell fate, proliferation, differentiation and apoptosis. Recent...