The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody

In the treatment of spinal cord injury, implantation of scaffolding biomaterials and the addition of neuroprotective factors will promote neural regeneration. It has been demonstrated in our previous work that linear ordered collagen scaffold (LOCS) will bridge neural regeneration after the injury of spinal cord hemisection, and BDNF fused with a collagen binding domain (CBD-BDNF) can bind to collagen specifically to exert the neuroprotective...