Sexual neurosteroids and synaptic plasticity in the hippocampus
Abstract
Sexual neurosteroids (SN), namely 17β-estradiol (E2) and 5α-dehydrotestosterone (DHT), are synthesized in the hippocampus, where they induce circuit modifications by changing the number of excitatory spine synapses in a paracrine and sex-specific manner. The mechanisms of this sex-specific synapse turnover, which are likely to affect cognitive functions, are poorly understood. We found that hippocampal neurons synthesize estradiol, which...
Paper Details
Title
Sexual neurosteroids and synaptic plasticity in the hippocampus
Published Date
Sep 1, 2015
Journal
Volume
1621
Pages
162 - 169
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