Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma
Abstract
Glioblastoma multiforme is the most commonly diagnosed malignant primary brain tumour in adults. Invasive behaviour is the pathological hallmark of malignant gliomas; consequently, its inhibition has been suggested as a therapeutic strategy. Tumour cell-derived gelatinases (matrix metalloproteinase-2, matrix metalloproteinase-9) can be considered prime factors in glioma invasiveness: their expression correlates with the progression and the...
Paper Details
Title
Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma
Published Date
Jun 1, 2010
Journal
Volume
168
Issue
2
Pages
514 - 522
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