Extension of the liquid chromatography/quantitative structure–property relationship method to assess the lipophilicity of neutral, acidic, basic and amphotheric drugs
Abstract
A reported chromatographic method to determine the 1-octanol/water partition coefficient (logP(o/w)) has been used to estimate the lipophilicity of 33 drugs with diverse structures and functionalities, including neutral, acid, basic, and amphoteric compounds. The applicability of the chromatographic method has been extended to the UHPLC technique, and the results obtained were compared to those obtained from conventional HPLC. No significant...
Paper Details
Title
Extension of the liquid chromatography/quantitative structure–property relationship method to assess the lipophilicity of neutral, acidic, basic and amphotheric drugs
Published Date
Jun 1, 2012
Journal
Volume
1240
Pages
113 - 122
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