Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin‐sensitive gi protein and ERK signaling pathway

Converging lines of evidence suggest that lanthanum tends to deposit in bone. The influence of lanthanum ion (La 3+ ) on osteoblast differentiation and the related mechanism are essential to understanding its effect on bone metabolism. In this study, La 3+ treatment enhanced in vitro osteoblast differentiation as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, and matrix mineralization. The expressions of...